| Michelle Jenner | Isabel de Castilla [DHR] | |
| Rodolfo Sancho | Fernando de Aragón [DHR] | |
| Pablo Derqui | Enrique IV [DHR] | |
| Bárbara Lennie | Juana de Avis [DHR] | |
| Pedro Casablanc | Alfonso Carrillo de Acuña [DHR] | |
| Ginés García Millán | Juan Pacheco [DHR] | |
| Ramon Madaula | Gonzalo Chacón [DHR] | |
| Sergio Peris Mencheta | Gonzalo Fernández de Córdoba [DHR] | |
| William Miller | Beltrán de la Cueva [DNR] | |
| Clara Sanchis | Isabel de Portugal [DNR] | |
| Víctor Elías | Alfonso de Castilla [DNR] | |
| Ainhoa Santamaría | Beatriz de Bobadilla [DNR] | |
| Pere Ponce | Gutierre de Cárdenas [DNR] | |
| Juan Meseguer | Diego de Mendoza [DNR] | |
| Jordi Banacolocha | Juan II de Aragón [DNR] | |
| Daniel Albaladejo | Alfonso V de Portugal [DNR] | |
| Cesar Vea | Pedro Girón [DNR] | |
| Arturo Querejeta | Alonso de Fonseca [DNR] | |
| Andrés Herrera | Pedro de Mendoza [DNR] | |
| Mónica Vic | Clara Alvarnáez [DNR] | |
| Jordi Díaz | Andrés de Cabrera [DNR] | |
| Nacho López | Alonso de Palencia [DNR] | |
| Ernesto Arias | Pedro de Peralta [DNR] | |
| Alberto Berzal | Pedro de Castilla [DNR] | |
| Malia Conde | Beatriz Pacheco [DNR] | |
| Mar del Hoyo | Mencía de Mendoza y Luna [DNR] | |
| Elisabet Gelabert | Catalina [DNR] | |
| Javier Rey | Diego Pacheco [DNR] | |
| Carmen Sanchez | Juana 'La Beltraneja' [DNR] | |
| Fernando Sansegundo | Antonio Veneris [DNR] | |
| David Boceta | Rodrigo de Ulloa [ENR] | |
| Jorge Bosch | Alejandro VI [ENR] | |
| Belén Constenla | Partera [ENR] | |
| Raúl Sanz | Álvaro de Zúñiga [ENR] | |
