Kyoto Ranbu

Chizuru Yukimura heads to Kyoto to search for her father, finding herself attacked by madden men before they are cut down by members of the Shinsengumi who take her into custody for interrogation. Upon learning that she is a girl and the daughter of a doctor who developed the Water of Life elixir that turns those that drink it into invincible blood lusting berserkers called Rasetsu (羅刹?, "Furies" in English dub), the Shinsengumi decide to keep her as an aide in their search. In time, as the Shinsengumi aid the shogunate in the Bakufu, Chizuru begins to develop a bond with the Shinsengumi and its aloof member Toshizo Hijikata. However, as time passes, Chizuru and Shinsengumi confront a mysterious faction who call themselves Oni (Devils) and that Chizuru is also an Oni with father revealed to be experimenting on the Water of Life to create the Rasetsu to wipe out the human race.