At the outbreak of the First World War, Marie Curie is already a renowned scientist, a winner of the Nobel Prize in Physics then in Chemistry. Her husband Pierre Curie met a sudden death eight years ago, and she has recently taken over as head of the Radium Research Institute beside Doctor Claudius Regaud. The urgency of the war situation and for the results of her research soon see her leaving her laboratory. Determined to establish brand-new radiology techniques, she and her 17-year-old daughter Irène travel the frontlines to convince financial backers, surgeons and doctors of the importance of using radiology. Meanwhile, Claudius Regaud, who has spent several years working on the radiological treatment of cancer, is seeking to develop new treatment and care methods for the field hospitals on the front. Both he and Marie will spend the four war years contributing to incredible advances in medicine and inventing the modern hospital. At the end of the war, the two researchers will found a treatment and care unit at the Radium Institute, combining both research and therapy.