| Bernd Blömer | Christian Matussek [DHR] | |
| Olga Buddecke | Lena von Behringhaus [DHR] | |
| Yunus Cumartpay | Ümit Demirci [DHR] | |
| Bejo Dohmen | Ben Nowak [DHR] | |
| Jasmin Hahn | Staatsanwältin Sonja Behrens [DHR] | |
| Alexander Hanfland | Claus Plewnia [DHR] | |
| Stefan König | Fabian Becker [DHR] | |
| Victoria Reich | Lola Schwickerath [DHR] | |
| Sabrina White | Anna Schilller [DHR] | |
| Murat Akin | Cem Ince [HR] | |
| Jan-Martin Müller | Ludger Retz (F: Schlaf schön) [HR] | |
| Natalie Renaud-Claus | Susanne Trettner [HR] | |
| Paulina Bachmann | Jana Blum [EHR] | |
| Carola Bambas | Frau Dr Schäfer [EHR] | |
| Sabine Barth | Laura Tempel [EHR] | |
| Nicolai Borger | Tom Stendal [EHR] | |
| Aleksan Cetinkaya | Tayfun Özgun [EHR] | |
| Laura Ehrich | Katharina Seidel [EHR] | |
| Sinan El Sayed | Ramin Balkhair (Ausgetanzt) [EHR] | |
| Nina Maria Föhr | Elvira Noack [EHR] | |
| Andreas Frakowiak | Peter Heinrichs [EHR] | |
| Peter Gatzweiler | Leonard [EHR] | |
| Holger Haas | Kai Hinrich (F: Kalter Fisch) [EHR] | |
| Sascia Haj | Elke Lorenz [EHR] | |
| Ruth Hamm | Yvonne Meinelt [EHR] | |
| Paul Hartmann | Max Hinrich [EHR] | |
| Ruth Hornemann | Claudia Brunner [EHR] | |
| Heike Huhmann | Silke Erdner [EHR] | |
| Anja Jacobsen | Linda Hinrich [EHR] | |
| Florian Kleine | Holger Knapp [EHR] | |
| Martin Kloss | Sven Kollmann [EHR] | |
| Verena Konietschke | Clarice Wempe [EHR] | |
| Viktor Krüger | Josef Krautner, murder suspect (main cast) [EHR] | |
| Luzie Kurth | Nettie Mannweiler [EHR] | |
| Caroline Leisau | Christiana Kossow (F: Mitten ins Herz) [EHR] | |
| Yannic Lippe | Sören Frohn [EHR] | |
| Isabelle Mann | Johanna Fink [EHR] | |
| Nicole Mieth | Romy & Amelie (Zwilling) [EHR] | |
| Mona Carina Nemec | Bella Pohl [EHR] | |
| Atilla Oener | Czem Yildiz [EHR] | |
| Stefan Pfau | Schreiner (F: Dopelt Gemoppelt) [EHR] | |
| Wolf E. Rahlfs | Michael Brummer [EHR] | |
| Jorres Risse | Frank Ockermann [EHR] | |
| Christiane Scheda | Ulla Schmitz [EHR] | |
| Lutz Scheffer | Rainer Strom [EHR] | |
| Johnny Schmitt | Fabian Maiwald [EHR] | |
| Hanna Scholz | Ina Lauer [EHR] | |
| Armin Sengenberger | Markus Trettner [EHR] | |
| Marc Alexander Sieder | Leon Brandes [EHR] | |
| Livia Steenken | Emma Bohlen [EHR] | |
| Barbara Stein | Nike Nullmayer [EHR] | |
| Maria Steurich | Gesine Kromer [EHR] | |
| Svea Timander | Claudia Gast [EHR] | |
| Viola Wedekind | Tanja Schlüter [EHR] | |
| Sybille Weiser | Kira [EHR] | |
| Christoph Wielinger | Udo Gebhard [EHR] | |
| Stefanie Wilpert | Linda [EHR] | |
| Beo Yalcin | Fatma Dogan [EHR] | |
| Hans-Günter Brünker | Dr. Jasper Niehoff (Pathologe) [DNR] | |
| Daniel Faust | Justus Bismarck [DNR] | |
| Sara Baric | Lisa [NR] | |
| Matthias Beier | Simon Wittek-Sommerschuh [NR] | |
| Delian Bewer | Tim Lindner [NR] | |
| Ludger Burmann | Gero Krieger [NR] | |
| Ayman Cherif | Pete Alvares [NR] | |
| Riccardo Ferreira | Leon [NR] | |
| Andreas Huhn | Torsten Buttgereit [NR] | |
| Ela Jako | Kind Lexi (Episode 31: "Der edle Ritter") [NR] | |
| Deniz Karaipek | Thomas Weichselbaum [NR] | |
| Martina Kock | Sophie Weber [NR] | |
| Alexander Peutz | Matze Pankhofer [NR] | |
| Elisa Posky | Bella Brocks [NR] | |
| Oskar Redfern | Murat Cengiz [NR] | |
| Magdalena M. Ritter | Beatrice Siebling [NR] | |
| Philipp Manuel Rothkopf | Hajo Lubitz [NR] | |
| Carolin Stähler | Petra Rüger [NR] | |
| Virginie Didier | Janine Brahms (F: Doppelt Gemoppelt) [ENR] | |
| Christopher Fliether | n.n. [ENR] | |
| Sarah Hirzinger | Jessica Weiß [ENR] | |
| Benjamin Monka | Timo Salzmann [ENR] | |
| Carsten Müller | Sporthotel Empfangschef Herbert Wolters [ENR] | |
| Alexander Leopold Schank | Arndt Tieber (Per Anhalter ins Verderben) [ENR] | |
| Theresa Stork | Angie Thoms (F: Das große Los) [ENR] | |
| Hellen-Swantje Wecker | Sylvia Witscher [ENR] | |
| Stefan Pescheck | Mike Kirner [TR] | |
| Marco Reinz | Lutz Friedrich - Vereinsvorstand [TR] | |
