Based on the bizarre actual life events of Dutch librarian and medical student, Hugo Bart Huges, Brainbloodvolume is a stylistic interpretation of the essential moments at which Huges chose to follow through with an operation he theorized would lead to a permanent state of higher consciousness – through the ancient mind-altering procedure of trepanation. Shot without dialogue in high-contrast black and white, the film approximates the style of the original 1965 photographs taken of Bart Huges during and after his operation, while utilizing a surreal tone and imagery throughout the story.