| Kevin Spacey | Francis Underwood [DHR] | Till Hagen |
| Robin Wright | Claire Underwood [DHR] | Irina von Bentheim |
| Michael Kelly | Doug Stamper [DHR] | Peter Flechtner |
| Mahershala Ali | Remy Danton [DNR] | Peter Lontzek |
| Sebastian Arcelus | Lucas Goodwin [DNR] | Jan Panczak |
| Jayne Atkinson | Außenministerin Catherine Durant [DNR] | Katharina Lopinski |
| Rachel Brosnahan | Rachel Posner [DNR] | Peggy Pollow |
| Reg E. Cathey | Freddy [DNR] | Axel Lutter |
| Derek Cecil | Seth Grayson [DNR] | Karlo Hackenberger |
| Terry Chen | Xander Feng [DNR] | Viktor Neumann |
| Kristen Connolly | Christina Gallagher [DNR] | Dascha Lehmann |
| Ben Daniels | Adam Galloway [DNR] | Detlef Bierstedt |
| Nathan Darrow | Edward Meechum [DNR] | Arne Stephan |
| Michael Gill | President Garrett Walker [DNR] | Frank Röth |
| Joanna Going | First Lady Tricia Walker [DNR] | Sabine Arnhold |
| Sandrine Holt | Gillian Cole [DNR] | Debora Weigert |
| Sakina Jaffrey | Linda Vasquez [DNR] | Franziska Pigulla |
| Kate Mara | Zoe Barnes [DNR] | Manja Doering |
| Gerald McRaney | Raymond Tusk [DNR] | Dieter Memel |
| Jimmi Simpson | Gavin Orsay [DNR] | Marcel Collé |
| Constance Zimmer | Janine Skorsky [DNR] | Victoria Sturm |
